Open AccessTransforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse
Author(s) -
Alvilusia Alvilusia,
Amir Fauzi,
Azhari Azhari,
Wresnindyatsih Wresnindyatsih,
Irsan Saleh
Publication year - 2016
Publication title -
indonesian journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2338-7335
pISSN - 2338-6401
DOI - 10.32771/inajog.v4i2.78
Subject(s) - tropoelastin , medicine , transforming growth factor , immunohistochemistry , gynecology , pathology , elastin
Objective: To know the correlation of the expression of transforming
growth factor beta (TGF-β1) and tropoelastin in uterine
prolapse.
Method: A cross-sectional study of 30 subjects suffered from uterine
prolapse in the Department of Obstetrics and Gynecology Dr. Mohammad
Hoesin hospital Palembang. The study was conducted
since December 1st, 2014 until July 31st, 2015. The sample was from
the sacrouterine ligament and immunohistochemical examination
was conducted to see the expression of TGF-β1 and tropoelastin.
Result: Of the 30 subjects obtained, the expression of TGF-β1 was on
30 subjects consisting of 18 (60%) for weak expression and 12
(40%) for strong expression. Meanwhile, the strong tropoelastin expression
was on 18 subjects (60%) and weak tropoelastin expression
on 12 subjects (40%). There was a positive correlation between
TGF-β1 and tropoelastin expression with moderate correlation
(p=0.014; r=0.44).
Conclusion: There is a positive correlation between the TGF-β1 and
tropoelastin expression of sacrouterine ligament in uterine prolapse
with moderate correlation.
[Indones J Obstet Gynecol 2016; 4-2: 70-74]
Keywords: transforming Growth Factor Beta 1, tropoelastin, uterine
prolapse