Open AccessHypoxia Inducible Factor1α in Correlation with Preeclampsia
Author(s) -
Hendrik Juarsa,
Hermie M. M. Tendean,
John Wantania
Publication year - 2016
Publication title -
indonesian journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2338-7335
pISSN - 2338-6401
DOI - 10.32771/inajog.v4i1.67
Subject(s) - preeclampsia , medicine , venous blood , obstetrics , hypoxia (environmental) , obstetrics and gynaecology , gynecology , positive correlation , blood sampling , pregnancy , oxygen , chemistry , genetics , organic chemistry , biology
Objective: To know the correlation between Hypoxia Inducible Factor
(HIF)-1α level with preeclampsia.
Method: The study was conducted at the Obstetrics and Gynecology
Department of Prof. Dr. R. D. Kandou Hospital. This research was
carried out from April to June 2014. This study is a cross-sectional
analytic approach in preeclampsia and normotensive pregnancy. We
perform cubital venous blood sampling for inspection by 5 ml of serum
and stored it in a refrigerator (-20°C). The level of HIF-1α serum
was done by quantitative ELISA method in Prodia Lab Jakarta.
Result: Seventy six pregnant women with 38 normotensive pregnancies
and 38 preeclampsia, showed a significant association between
the average levels of HIF-1α in the serum of pregnant women
with preeclampsia compared to normotensive pregnancies (p =
0.000).
Conclusion: There is a positive relationship between the levels of
HIF-1α in serum of preeclampsia, in which HIF-1α levels in preeclampsia
was higher than normotensive pregnancies.
[Indones J Obstet Gynecol 2016; 1: 19-22]
Keywords: hypoxia inducible factor-1α, preeclampsia