Open AccessTreatment Response of PlatinumBased Chemoradiation on Locally Advanced Cervical Cancer
Author(s) -
Oni Khonsa,
Sigit Purbadi,
Nana Supriana,
Bambang Sutrisna
Publication year - 2016
Publication title -
indonesian journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2338-7335
pISSN - 2338-6401
DOI - 10.32771/inajog.v3i4.57
Subject(s) - medicine , ifosfamide , cisplatin , cervical cancer , concomitant , stage (stratigraphy) , oncology , toxicity , chemotherapy , surgery , urology , cancer , paleontology , biology
Objective: To evaluate the efficacy (treatment response), toxicity,
and overall survival of concomitant chemoradiation (CRT) with
three-weekly cisplatin-ifosfamide compared to CRT with weekly cisplatin
in advanced stage cervical cancers (stage IIB-IIIB).
Method: This is a historical cohort between 32 patients receiving
CRT with three-weekly cisplatin and ifosfamide and 29 patients receiving
weekly cisplatin in Gynecologic Oncology division outpatient
clinic and ward, Dr. Cipto Mangunkusumo Hospital.
Results: There was no significant difference in treatment response,
overall and disease-free survival. There was more gastrointestinal
toxicity in the cisplatin-ifosfamide arm compared to the other arm
(p=0.014), but other toxicity effects were not different.
Conclusion: Platinum based-chemoradiation has the same efficacy
in terms of treatment response for locally advanced cervical cancer.
[Indones J Obstet Gynecol 2015; 3-4: 212-221]
Keywords: cisplatin, concomitant chemoradiation, ifosfamide, locally
advance stage cervical cancer