Open Accessp53 Gene Codon 72 Polymorphisms among Cervical Carcinoma Patients
Author(s) -
Rustham Basyar,
Agustria Z Saleh,
Irawan Sastradinata,
Yuwono Yuwono
Publication year - 2016
Publication title -
indonesian journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2338-7335
pISSN - 2338-6401
DOI - 10.32771/inajog.v3i3.48
Subject(s) - genotype , medicine , allele , cervical carcinoma , observational study , gene , oncology , carcinoma , cervical cancer , allele frequency , gynecology , gastroenterology , genetics , biology , cancer
Objective: To identify the association between p53 gene codon 72
polymorphism and cervical carcinoma.
Method: An analytic observational study with case-control design,
from November 2013 until March 2014 in the Department of Obstetrics
and Gynecology and Microbiology Laboratory Faculty of Medicine,
Sriwijaya University, Dr. Moh. Hoesin Hospital Palembang.
Result: In total there are 100 samples analyzed consisting of 50 subjects
and 50 control groups. Genotype distribution in subject group
are 54% Arg/Arg, 42% Pro/Arg and 4% Pro/Pro, and in control
group are 36% Arg/Arg, 46% Pro/Arg and 18% Pro/Pro. Arg/Arg
genotype is at risk of cervical carcinoma 6.7 times higher compared
with Pro/Pro genotype (p=0.013; OR 6.75; 95% CI 1.34-34.94). Arg
allele in the p53 gene codon 72 increase the risk of cervical carcinoma
2.6 times more than Pro allele.
Conclusion: Proline mutation to Arginine in gene p53 P72R is one of
the risk factor for cervical carcinoma.
Keywords: arginine, cervical carcinoma, gene p53 codon 72, polymorphism,
proline