Open AccessIMMOBILIZATION OF LEVOTHYROXINE IN QUATERNIZED N,N-DIETYL N-METHYL CHITOSAN HYDROGEL AND CHEMICAL NATURE OF THE INTERACTION
Author(s) -
Samira Safaraliyeva,
A.F. Hummetov,
Sh.Z. Tapdiqov,
Sevda Fatullayeva,
Maria Grazia Raucci,
D.B. Tagiyev,
N.А. Zeynalov
Publication year - 2022
Publication title -
azərbaycan kimya jurnalı/azerbajčan himiâ žurnaly
Language(s) - English
Resource type - Journals
eISSN - 2522-1841
pISSN - 0005-2531
DOI - 10.32737/0005-2531-2022-1-6-12
Subject(s) - chitosan , chemistry , hydrogen bond , sorption , polymer chemistry , infrared spectroscopy , levothyroxine , methyl iodide , salt (chemistry) , nuclear chemistry , adsorption , organic chemistry , molecule , hormone , biochemistry
Immobilization of a thyroid hormone substitute of L-thyroxine on chitosan-based smart hydrogel structure was performed to reduce the side effects of the required daily dose. The hydrogel was obtained by the Schiff reaction of chitosan with acetaldehyde and quaternization with methyl iodide then by ion exchange with NaCl salt. Finally, a hydrogel was obtained from the treatment of chitosan-based salt at -200C. The amount of levothyroxine immobilized by physical sorption on the hydrogel was determined by molecular electron spectroscopy on basis especially absorption peak at 227 nm. Results of IR- and UV-Vis spectroscopic analyses revealed that the interaction between levothyroxine and hydrogel occurs mainly due to hydrogen bonding and orientation forces of intermolecular interaction