Open AccessMolecular Review: Effects of Physical Exercise in Skeletal Muscle Glucose Uptake
Author(s) -
Rahmi Rahmi
Publication year - 2021
Publication title -
sumatera medical journal
Language(s) - English
Resource type - Journals
eISSN - 2622-9234
pISSN - 2622-1357
DOI - 10.32734/sumej.v4i1.4785
Subject(s) - glut4 , glucose transporter , intracellular , glucose uptake , ampk , skeletal muscle , contraction (grammar) , chemistry , muscle contraction , biophysics , chromosomal translocation , microbiology and biotechnology , medicine , endocrinology , biochemistry , biology , phosphorylation , insulin , gene , protein kinase a
Muscle contraction requires glucose as its main fuel. Glucose enters the muscle cells through diffusion facilitated by GLUT4. GLUT4 must be translocated from intracellular to the plasma membrane and T tubules during muscle contraction. This literature review will discuss how physical exercise can signal GLUT4 translocation for glucose uptake. Molecular signals induced by physical exercise are very complex and involve various molecules, one of which is AMPK and intracellular Ca concentration.