Open AccessPoguntano Herba Extract Immunostimulant Activities (Picriafel-terraeLour). in Immunosupression Rats Infected by Staphylococcus aureus Against Total Leukocytes and Differential Leukocytes
Author(s) -
Anggitha Ningtias,
. Rosidah,
Yuandani Yuandani
Publication year - 2021
Publication title -
indonesian journal of pharmaceutical and clinical research
Language(s) - English
Resource type - Journals
eISSN - 2620-3731
pISSN - 2615-6199
DOI - 10.32734/idjpcr.v4i1.5378
Subject(s) - immunostimulant , herb , traditional medicine , staphylococcus aureus , ethyl acetate , flavonoid , ethanol , medicine , medicinal herbs , microbiology and biotechnology , biology , immunology , bacteria , immune system , biochemistry , antioxidant , genetics
Poguntano (Picriafel-terraeLour.) is a medicinal plant in North Sumatra that has been used in traditional medicine to treat degenerative diseases.Poguntano extract contains flavonoid compounds that have the potential to be developed into immunomodulators. This study showed the immunostimulant activity of poguntano herb n-hexane extract (PHNHE), poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) in immunosuppressed rats infected with Staphylococcus aureus. The evidence of poguntano herb as an immunomodulator was carried out by testing total leukocytes and differential leukocytes. Poguntano herb n-hexane extract (PHNHE) can not increase the total and differential leukocytes; Poguntano herb ethyl acetate extract (PHEAE) and poguntano herb ethanol extract (PHEE) can increase the total and differential leukocytes in immunosuppressed rats induced by Staphylococcus aureus.