Antimicrobial activity and therapeutic efficacy of thiacycline in subclinical mastitisin sheep

Relevance. The work is devoted to the results of studying of the antimicrobial and therapeutic efficacy of the drug thiacycline in subclinical mastitis in sheep. The aim of our research еsеwas to study the antimicrobial activity and therapeutic efficacy of thiacycline in subclinical mastitis in lactating ewes. Methods. The study of antimicrobial activity was carried out by the method of serial dilutions in a liquid nutrient medium, on the basis of the Caspian zonal NIVI in the laboratory on the study of diseases of non-infectious etiology of farm animals. The therapeutic efficacy of thiacycline was studied in the SEC "Bukhti" of the Gunib district of Dagestan Republic on ewes of the Dagestan rock, aged from 3 to 5 years, with subclinical mastitis, in the amount of 51 heads. Animals on the basis of analogues were divided into two groups: experience ( n = 26), control ( n = 25). The animals of the experimental group were treated with thiacycline, the drug was administered intramuscularly, once a day, in dose 0.1 ml/kg. The test combination drug thiacycline developed by VIC. The control group was treated with bicillin-3, in dose 600,000 units per head, with an interval 72 hours. Results. The complex antibacterial drug thiacycline has a wide spectrum and high antimicrobial effect against museum strains and potential causative agents of sheep mastitis. The therapeutic efficacy of thiacycline in the treatment of subclinical mastitis in sheep – 97.0%, which is on 13.0% higher compared to bicillin-3. On the 7th day after the last administratin of preparation all the physicochemical parameters of milk corresponded to the physiological norm.