Open AccessDevelopment and Validation of Absorption Correction UV-Spectrophotometry Method for Simultaneous Estimation of Ranitidine HCL and Dicyclomine Hydrochloride in Their Marketed Formulation
Author(s) -
Bhumi Kantariya,
Griva Bhatt,
Mehul Mehta,
Urmi Kanatria,
Ravi Dalsaniya
Publication year - 2019
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst218140
Subject(s) - ranitidine hydrochloride , chromatography , dosage form , methanol , chemistry , spectrophotometry , absorption (acoustics) , solvent , ultraviolet visible spectroscopy , ranitidine , materials science , pharmacology , medicine , organic chemistry , composite material
A Simple, selective, precise and rapid absorption correction Spectrophotometric method has been developed and validated as per ICH guideline for the simultaneous estimation of Ranitidine Hydrochloride and Dicyclomine Hydrochloride in tablet dosage form. Method is base on UV Spectrophotometric for determination of two drug, by using Methanol as a solvent and diluted the same with 0.1N NaOH, solution. In this UV method, the two wavelength were selected, 311.4 nm and at 217 nm for RANTD and DICY, respectively. this method was validated according to ICH guideline and Linearity range, was found to be 7.5-37.5 µg/ml and 1-5 µg/ml for RANTD and DICY, respectively. The method was successfully applied to assay drugs in tablet.