Open AccessEffect of Different Solvents on Biginelli Reaction Using Layered Double Hyroxide (LDH) As an Ecofriendly Catalyst
Author(s) -
N. S. Ghotkar,
D. A. Pund,
B. N. Berad
Publication year - 2021
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst218128
Subject(s) - yield (engineering) , catalysis , biginelli reaction , hydroxide , condensation , solvent , chemistry , one pot synthesis , organic chemistry , nuclear chemistry , materials science , metallurgy , physics , thermodynamics
A simple and efficient method of the 3,4- dihydropyrimidin-2(1H)-ones/thiones synthesis in good to high yield is described. It consists in a one-pot three-component Biginelli condensation using Layered double hydroxide (LDH) as catalyst. The effect of different solvents on the yields of final product also been studied. Highly polar solvent as well as highly non-polar gives less yields in presence of LDH catalyst.