Open AccessSynthesis, Characterization of Novel Benzothiophene
Author(s) -
Veerappan Jeyachandranan
Publication year - 2021
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst207669
Subject(s) - knoevenagel condensation , malononitrile , domino , tautomer , intramolecular force , chemistry , benzothiophene , organic chemistry , condensation reaction , michael reaction , combinatorial chemistry , catalysis , thiophene
A library of novel benzo[b] thiophenehave been synthesized regioselectively in good yields through the one-pot domino reactions of thiophenone, malononitrile and aromatic aldehydes in the presence of NaOEt. This transformation presumably involves Knoevenagel condensation–Michael addition–intramolecular Thorpe-Ziegler cyclization-Tautomerization-Elimination sequence of reactions.