Open AccessA Review on Plant Derived Efflux Pump Inhibitors Targeting nor An Efflux Pump in Staphylococcus Aureus
Author(s) -
Arya Mohan,
A. R. Nisha,
V. Keerthika
Publication year - 2020
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst20754
Subject(s) - efflux , staphylococcus aureus , antimicrobial , antibiotic resistance , antibiotics , microbiology and biotechnology , chemistry , bacteria , biology , biochemistry , genetics
Staphylococcus aureus is an important human and animal pathogen which develops resistance against various antibiotics. One of the reasons for the emergence of resistance is through efflux pumps which extrude the antibiotic out of bacterial cell. NorA is the most extensively studied efflux pumps in S. aureus which effluxes the fluoroquinolones, dyes and quaternary ammonium compounds. These efflux pumps can be inhibited by various natural and synthetic agents. Owing to the harmful effects of synthetic agents, the natural efflux pump inhibitors derived from various plant sources stands as a promising moiety in combating antimicrobial resistance. Even though there are many constraints in marketing the plant derived efflux pumps as therapeutic agents, it still finds a place in combating antimicrobial resistance.