Open AccessGreen approach to Chemo-Selective N-Boc Protection of Amines using Catalytic amount of Lithium Hydroxide Monohydrate under Solvent Free Condition
Author(s) -
Sandip P. Gondake,
S. R. Kshirsagar,
Ashok S. Pise,
Valmik S. Kapase,
Sagar I. Shinde
Publication year - 2020
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst20751
Subject(s) - lithium hydroxide , chemistry , hydroxide , solvent , catalysis , amine gas treating , dimethyl carbonate , lithium (medication) , lithium carbonate , nuclear chemistry , organic chemistry , medicine , ion , ion exchange , ionic bonding , endocrinology
The protecting group plays important role in synthesis of multifunctional targets. A simple rapid efficient and green method for chemo-selective N-Boc protection of amines using Lithium hydroxide as a green catalyst. In the present work amine protection in presence of ditert-butyl carbonate under solvent free condition is carried out. An efficient green protocol for chemoselctive N-Boc protection of aryl, aliphatic, aromatic, acyclic and hetero cyclic amines (1 m mol %)( 10, 20, 30) were carried out with ditert-butyl carbonate (Boc)2 O using Lithium hydroxide monohydrate (10 mol %) at room temperature under solvent free condition to give white solid monitored on TLC. No side reactions are observed .The present protocol were simple, rapid, efficient, shorter reaction times, high yielding, highly selective, economical and eco-friendly