Open AccessOne-Pot Green Method for the Synthesis of Oxazine Derivatives Under Aqueous Medium
Author(s) -
S. R. Kshirsagar,
Ashok S. Pise,
Sagar I. Shinde,
Sandip P. Gondake,
Valmik S. Kapase
Publication year - 2020
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst207482
Subject(s) - aniline , environmentally friendly , aqueous medium , formaldehyde , catalysis , green chemistry , condensation , condensation reaction , chemistry , organic chemistry , aqueous solution , combinatorial chemistry , reaction mechanism , ecology , physics , thermodynamics , biology
A simple, convenient, and environmentally friendly method for the synthesis of 1,3-oxazine derivatives has been developed under aqueous conditions. The reaction proceeds via one pot multicomponent condensation of ? or ?- naphthol, aromatic aniline and formaldehyde using polyphosphoric acid as green catalyst. The current protocols are simple, requires less reaction time and provides high yields. Non-polluting synthetic procedures are used to avoid harmful effects of organic solvents on the environment.