Microwave Assisted Synthesis, Antimicrobial and Anti-inflammatory Potential of Some Novel 1,2,4-triazole Derivatives

A series of 1,2,4-triazole derivatives were synthesized under microwave irradiation and characterized by IR, 1H-NMR, and mass spectral data. Pathogenic microorganisms are causative agents for different types of serious infectious diseases. Despite advancements in medication, bacterial infections continue to be a growing problem in health care. As more and more bacteria become resistant to antibiotics used in therapy there is considerable interest in the development of new compounds with antimicrobial activity. Inflammation is a central part of the response to injury and infection in the immune system. It may become problematic if the inflammatory process continues for too long. External infections involving the skin and wound are the most frequent complications affecting humans and animals. The compounds containing a heterocyclic ring play an important role among organic compounds with biological activity used as drugs in human, veterinary medicine or as insecticides and pesticides in agriculture. The compounds were evaluated for their in antimicrobial and anti-inflammatory activity against some strains of bacteria. The pharmacological evaluation of 1,2,4-triazole derivatives revealed that, among all the compounds screened compound code 2b showed leading antibacterial activity against the selected pathogenic strains of bacteria and compound code 2e were found to have promising anti-inflammatory activity.