Open AccessA Review on Computer - Aided Formulation Development
Author(s) -
Rohan G. Chaudhari,
Dhananjay Raut,
P A Barhewar,
Ashish Mali,
Kishorkumar Burade
Publication year - 2019
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst196658
Subject(s) - computer science , microemulsion , quality by design , development (topology) , computer aided , quality (philosophy) , engineering , mathematics , pulmonary surfactant , mathematical analysis , operations management , chemical engineering , downstream (manufacturing) , programming language , philosophy , epistemology
This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self- microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and arti?cial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality- by-design development of pharmaceutical emulsion and (self) microemulsion formulations.