Open AccessFormulation, Development and Evaluation of Bilayer Tablet of Flurbiprofen
Author(s) -
Nitin A. Gaikwad,
Indrjeet V Mane,
Manohar D. Kengar,
Ranjeet S Jadhav
Publication year - 2019
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst196130
Subject(s) - granulation , flurbiprofen , bilayer , dissolution , starch , chemistry , materials science , chromatography , chemical engineering , composite material , membrane , pharmacology , biochemistry , organic chemistry , medicine , engineering
In the Study of Formulation of Bilayer Tablet of Flurbiprofen the Following Materials Using sodium starch glycolate as immediate release and HPMC K15 in different ratios as release retardant materials using a wet granulation method. All tablets exhibited good physical properties with Respect to appearance, content uniformity, hardness, weight variation and Invitro dissolution data show at increasing proportions Of sodium starch glycolate for immediate release whereas HPMC K15sustaineddrugreleaserate. The bilayer tablets showed an initial release of drug In about1hr, then sustaining the release for 12h, The kinetic analysis of dissolution data showed that release was observe din these tablets. When data was fitted to the Higuchi model. Bilayer tablets of flurbiprofen can be successfully formulated Using sodium starch glycolate and HPMC K15 in different ratios as release retardant materials employing a wet granulation method.