Open AccessA Detailed Bromination Study of 7-Hydroxy-4-Methyl Benzopyran-2-One Under Classical Method and Microwave Irradiation
Author(s) -
Vijay D. Gangan,
Ajaykumar C. Singh,
R. D. Joshi,
Amod V. Tamhankar,
Kalpana J. Bhatwadekar,
Shyamlal T. Yadav,
Suyog S. Daye,
Dattatraya A. Dute,
Sakharam K. Godage,
Manoj Yewale,
Gaurav Pimple,
Arjun L. Ghorpade
Publication year - 2019
Publication title -
international journal of scientific research in science and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-602X
pISSN - 2395-6011
DOI - 10.32628/ijsrst1196231
Subject(s) - halogenation , benzopyran , microwave irradiation , coumarin , chemistry , microwave , derivative (finance) , solvent , irradiation , organic chemistry , medicinal chemistry , physics , catalysis , quantum mechanics , nuclear physics , financial economics , economics
7-Hydroxy-4-methyl benzopyran-2-one, Benzopyran a class of coumarin derivative, has been subjected for bromination under classical method, microwave irradiation and solvent-free protocol for allylic and vinylic bromination using liquid Br2, organic bromides, NBS, HBr-H2O2 and DDH as brominating agent under different protic and aprotic solvents. The efficacy of the bromination of benzopyran under classical method and microwave irradiation has been established. The effects of the bromination and location of the substituents on the outcome of the reaction have been rationalized by using 1H NMR and IR spectrum. Few of them showing promising antibacterial activity.