Synthesis, Characterization and Biological Activity Of 1, 4-Dihydropyrimido [1,2-A] Benzimidazole | Zendy

Vaishnavi. P. Gilava | Zendy; Praful K. Patel | Zendy

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Synthesis, Characterization and Biological Activity Of 1, 4-Dihydropyrimido [1,2-A] Benzimidazole

Author(s) -

Vaishnavi. P. Gilava,

Praful K. Patel

Publication year - 2021

Publication title -

international journal of scientific research in science engineering and technology

Language(s) - English

Resource type - Journals

eISSN - 2395-1990

pISSN - 2394-4099

DOI - 10.32628/ijsrset218630

Subject(s) - benzimidazole , antimicrobial , gram , amine gas treating , elemental analysis , chemistry , combinatorial chemistry , nuclear chemistry , medicinal chemistry , organic chemistry , bacteria , biology , genetics

An effectual direct synthesis of 1,4-dihydropyrimido[1,2-a]benzimidazole (C-01 to C-10) was developed from 1H-benzo[d]imidazol-2-amine, 4-(benzyloxy)-3-methoxybenzaldehyde, N-(substituted phenyl)-3-oxobutanamide by adding few drop of DMF and in presence of conc.HCL. The product was obtained after about 5 hours of heating in refluxing condition. The synthesized compounds were characterized by different spectral and elemental analysis. Some of the obtained compounds showed a promising antimicrobial activity on screening against Gram-positive and Gram-negative bacterial strains.

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