Open AccessSpectrophotometric determination of Rivaroxaban in bulk drug and oral dosage formulation
Author(s) -
Vikramsinh R. Chauhan,
Deepak Sharma,
K. B. Vyas
Publication year - 2019
Publication title -
international journal of scientific research in science, engineering and technology
Language(s) - English
Resource type - Journals
eISSN - 2395-1990
pISSN - 2394-4099
DOI - 10.32628/ijsrset207452
Subject(s) - rivaroxaban , bromocresol green , chromatography , pharmaceutical formulation , dosage form , relative standard deviation , drug , spectrophotometry , chemistry , materials science , mathematics , pharmacology , medicine , detection limit , atrial fibrillation , warfarin , cardiology
A simple, rapid, cost effective and extractive UV-Vis spectrophotometric method has been developed for the determination of Rivaroxaban (RIV) in bulk drug and pharmaceutical formulation. It was based on UV-Vis spectrophotometric measurements in which the drug made a complex with bromocresol green dye (BCG) in acidic medium and give stable pale yellow colored complex which exhibits absorption maximum at 416 nm. Beer’s law was obeyed in the concentration range of 2 - 40 ?g /ml. This method was tested and validated for various parameters according to ICH guidelines. The proposed method was successfully applied for the determination of RIV in oral formulation. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation < 2 %). As it is simple, cheap and less time consuming, it can be suitably applied for the estimation of RIV in dosage forms in quality control labs.