Open AccessRecombinant Human Cyclophilin A In Vitro Inhibits the Formation of Fibrin Clot
Author(s) -
Yu. A. Morozov,
Л. М. Хромых,
I. I. Dementieva,
M. A. Charnaia,
Н. А. Куликова,
Dmitry Kazansky
Publication year - 2012
Publication title -
acta naturae
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 26
ISSN - 2075-8251
DOI - 10.32607/actanaturae.10655
Subject(s) - cyclophilin a , fibrin , cyclophilin , in vitro , chemistry , recombinant dna , biophysics , thrombin , microbiology and biotechnology , factor xiii , fibrinogen , biochemistry , immunology , platelet , biology , gene
The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of inhibiting in vitro the formation of a fibrin clot, thereby violating the spatial dynamics of clot growth; this effect is transient and dose-independent. Furthermore, the hypothesis that the conformational changes in the thrombin-rhCyA complex may mediate the anticoagulant effect of rhCyA on the autowave processes of blood clotting is postulated.