Open AccessAntibacterial Effect of Thiosulfinates on Multiresistant Strains of Bacteria Isolated from Patients with Cystic Fibrosis
Author(s) -
Vitalia V. Kulikova,
M. Chernukha,
Elena A. Morozova,
Svetlana V. Revtovich,
A. N. Rodionov,
V. P. Koval,
L.R. Avetisyan,
Д. Г. Кулястова,
I.A. Shaginyan,
Tatyana V. Demidkina
Publication year - 2018
Publication title -
acta naturae
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 26
ISSN - 2075-8251
DOI - 10.32607/20758251-2018-10-3-77-80
Subject(s) - microbiology and biotechnology , cystic fibrosis , allicin , antibiotics , bacteria , antibacterial activity , antibacterial agent , multiple drug resistance , chemistry , biology , medicine , biochemistry , genetics
The multiresistance of A. ruhlandii 155B, B. cenocepacia 122, and P. aeruginosa 48B strains isolated from patients with cystic fibrosis was established. The antibacterial effect of allicin, dimethyl thiosulfinate, and dipropyl thiosulfinate on multidrug-resistant strains was shown. Thiosulfinates can have both bacteriostatic and bactericidal effects depending on the microorganism and the concentration. The studied thiosulfinates may be candidates for the development of alternative antibiotic drugs to treat infections caused by multidrug-resistant pathogens.