Open AccessEndocrine-Disrupting Chemicals Role in Drug Abuser: A Review Study
Author(s) -
Idha Arfianti Wiraagni,
Ali Mustafa,
Rusdi Abd Rashid,
Didi Erwandi Bin Mohamad Haron
Publication year - 2020
Publication title -
international journal of medical toxicology and forensic medicine
Language(s) - English
Resource type - Journals
eISSN - 2251-8770
pISSN - 2251-8762
DOI - 10.32598/ijmtfm.v10i4.26324
Subject(s) - paraben , endocrine system , drug , medicine , estrogen , monoaminergic , dopamine , craving , monoamine neurotransmitter , addiction , pharmacology , serotonin , hormone , physiology , endocrinology , preservative , biology , psychiatry , food science , receptor
Endocrine-disrupting Chemicals (EDCs) are exogenous chemicals that influence many aspects of natural hormone actions. Bisphenol is used in the industry, for increasing the thickness and durability of materials in certain plastics and resins. Paraben is used as preservatives in many pharmaceuticals, cosmetics, and some food products. EDCs can increase estrogen levels inside the body, and estrogen itself can increase the monoamine effect (dopamine, serotonin), neuronal excitability, neuropeptide transmitter mechanism, and drug metabolism. In drug abusers, this effect can develop greater craving behavior, addiction, and relapse.