Open AccessSpike protein of SARS-COV-2 as a potential target for phytochemical constituents: A literature review
Author(s) -
Maira Ahmad,
Sehrish Rashid,
Taseer Ahmad
Publication year - 2021
Publication title -
journal of shifa tameer-e-millat university
Language(s) - English
Resource type - Journals
eISSN - 2617-8109
pISSN - 2617-8095
DOI - 10.32593/jstmu/vol4.iss2.169
Subject(s) - coronaviridae , spike (software development) , spike protein , coronavirus , biology , covid-19 , virology , computational biology , medicine , computer science , disease , software engineering , pathology , infectious disease (medical specialty)
SARS-CoV-2 belongs to well-known SARS Coronaviridae family. One of the main structural proteins of SARS-CoV-2 is the spike protein that is present around the surface of a viral cell and plays an essential role in viral attachment, fusion and invasion in host cell. Once a virus invades a cell, it replicates and infects other cells. The fundamental role of spike protein in the progression of viral infection has led to an increased interest in exploring agents that target the viral spike protein for effective control of CoVID-19. The related data from published articles reviewed and numerous phytochemicals that reportedly target the spike proteins of coronaviruses by computational studies briefly discussed. These active constituents possess the potential to develop as therapeutic and antiviral agents against SARS-CoV-2.