Open AccessRole of Diffusion Tensor Imaging Combined with Neuron-Specific Enolase and S100 calcium-binding protein B Detection in Predicting the Prognosis of Moderate and Severe Traumatic Brain Injury
Author(s) -
Peng Chen,
Xiao Yu,
Tao Huang,
Yongbing Deng,
Jingrui Huang
Publication year - 2021
Publication title -
iranian red crescent medical journal
Language(s) - English
Resource type - Journals
ISSN - 2074-1804
DOI - 10.32592/ircmj.2021.23.4.261
Subject(s) - enolase , traumatic brain injury , fractional anisotropy , medicine , glasgow coma scale , diffusion mri , glasgow outcome scale , corpus callosum , gastroenterology , pathology , magnetic resonance imaging , anesthesia , immunohistochemistry , radiology , psychiatry
Background Traumatic brain injury (TBI) seriously affects the quality of life of patients. The present study evaluated the role of diffusion tensor imaging (DTI) combined with Neuron-Specific Enolase (NSE) and S100 calcium-binding protein B (S100B) protein in predicting the prognosis of moderate and severe TBI.Methods The TBI patients were divided into moderate TBI (TBIm) and severe TBI (TBIs) groups according to the Glasgow Coma Scale (GCS) after admission. The patients were then divided into good and poor prognosis groups according to the Glasgow Outcome Scale (GOS); moreover, their follow-ups were recorded at 3 and 6 months after injury. This study also included 65 healthy individuals with matched age and gender as the control group. The fractional anisotropy (FA) values of DTI, serum neuron-specific enolase (NSE), and S100B protein levels were detected in this study. The data were analyzed in SPSS software (version 22.0) to evaluate the role of DTI combined with NSE and S100B protein in predicting the prognosis in TBIm and TBIs.Results: After TBI, the FA values of DTI in the TBI group were lower than those in the control group (P 0.05). The serum levels of NSE and S100B in the good prognosis group were significantly lower than those in the poor prognosis group (P 0.05).Conclusion Although DTI combined with NSE and S100B protein can effectively predict the prognosis of patients with moderate and severe TBI in the early stages, various other measures have been used in the studies to predict the prognosis of TBI patients. Accordingly, comparison with other measures is essential in further studies.