Open AccessEVALUATION OF LEARNING AND MEMORY IN RATS THROUGH ELEVATED PLUS MAZE MODEL
Author(s) -
Manju Gari,
Manisha Varshney
Publication year - 2020
Publication title -
journal of biomedical and pharmaceutical research
Language(s) - English
Resource type - Journals
eISSN - 2589-8752
pISSN - 2279-0594
DOI - 10.32553/jbpr.v9i2.727
Subject(s) - dementia , medicine , disease , cognition , morris water navigation task , neuroscience , psychology , pharmacology , psychiatry
The understanding of dementia has evolved over 2500 years, from a vague notion of unavoidable age-related memory loss, to a present understanding of its characteristic clinical and pathologic features. Alzheimer disease (AD) symptoms include decline in cognitive function and it is most common form of dementia. In this pharmacological study two drugs Metformin and Bacopa monnieri have been tested to evaluate their efficacy in treatment of AD using Elevated Plus Maze model by evaluating effect of these drugs on learning and memory in rats. The results shown during experiments are promising by both these drugs in improvement of learning and memory in rats, and therefore could be the potential therapy in treatment of AD as well.