Open AccessThe Synthesis and Evaluation of anti-tubercular activity for some new 4-{4-[(hydrazinylmethoxy) (hydroxy)methyl]phenyl}-3-methyl-3,4dihydro quinoxalin -2(1H)-one novel Derivatives.
Author(s) -
Shripad Potadar,
Ramling Kotnal
Publication year - 2020
Publication title -
journal of biomedical and pharmaceutical research
Language(s) - English
Resource type - Journals
eISSN - 2589-8752
pISSN - 2279-0594
DOI - 10.32553/jbpr.v8i6.703
Subject(s) - quinoxaline , chemistry , proton nmr , elemental analysis , spectral analysis , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , spectroscopy , physics , quantum mechanics
A new series of 4-{4-[(hydrazinylmethoxy)(hydroxy)methyl]phenyl}-3-methyl-3,4dihydro quinoxalin -2(1H)-one were designed and synthesized in order to evaluate their anti-tb activity. The structure of the synthesized compounds was confirmed by elemental analysis and spectral data (IR, 1H NMR and Mass). The data obtained from biological screening revealed that; synthesized compounds showed the good to moderate anti-tb activities.
Keywords: Quinoxaline, ortho-phenylenediamine and hydrazinehydrate.