Open AccessMETHYLATION OF PROLACTIN AND OXYTOCIN HORMONE GENES; PHYSIOLOGICAL FUNCTIONS AND ROLES IN DISEASE STATES
Author(s) -
Manoj Tyagi,
Deepak Gopal Shewade,
Megha Chaudhary,
Mohammed I Wani,
Shyam S Yadav
Publication year - 2019
Publication title -
journal of biomedical and pharmaceutical research
Language(s) - English
Resource type - Journals
eISSN - 2589-8752
pISSN - 2279-0594
DOI - 10.32553/jbpr.v8i2.584
Subject(s) - prolactin , epigenetics , dna methylation , oxytocin , oxytocin receptor , methylation , biology , gene silencing , lactation , gene , hormone , prolactin receptor , endocrinology , genetics , gene expression , pregnancy
DNA methylation is the key mechanism in epigenetic events involved in gene silencing and gene genome stability. The two important hormones involved in social behaviour, lactation and parturition are Oxytocin and Prolactin. There is growing interest in epigenetic modification of oxytocin and prolactin in neurotransmission interaction and their functional significance. This review outlines the influence of DNA methylation of genes of oxytocin and prolactin hormones/receptors and impact on their biological roles and influence on endocrine function in mammals.
Keywords: Prolactin, Oxytocin, receptor, DNA methylation, epigenetics