Open AccessFUNCTIONAL ROLES OF LIPID METABOLITE CDP DIACYLGLYCEROL AND ITS SYNTHASE ENZYMES: RECENT DEVELOPMENTS
Author(s) -
Manoj Tyagi,
Dharmendra Singh,
Joyce Nirmala,
Mohammed Amil,
Shyam S Yadav
Publication year - 2019
Publication title -
journal of biomedical and pharmaceutical research
Language(s) - English
Resource type - Journals
eISSN - 2589-8752
pISSN - 2279-0594
DOI - 10.32553/jbpr.v8i1.572
Subject(s) - diacylglycerol kinase , phosphatidic acid , phosphatidylglycerol , phosphatidylinositol , biochemistry , chemistry , enzyme , phosphatidylserine , signal transduction , phospholipid , cytidine , lipid signaling , membrane , phosphatidylcholine , protein kinase c
Phospholipids are basic building-block molecules for biological membranes. Biosynthesis of phospholipids i.e phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthase (CDS) is an integral membrane enzyme catalysing the formation of CDP-DAG, an essential step for phosphoinositide recycling during signal transduction. New roles are being ascribed to the CDP-DAG in signalling and pathophysiological conditions. This pathway may also be the target of novel drugs to be used in neuro-psychiatric conditions.
Key words: Phospholipids, Cytidine diphosphate, diacylglycerol, phosphatidic acid, phosphatidylglycerol.