Synthesis and Biological Evaluation of N-Heterocyclic Substituted Fluoro-Benzothiazole Sulphonamido Analogs as a Potential Therapeutic Agents | Zendy

Sri Ranga. T | Zendy; Neelesh Chaubey | Zendy

Open Access

Synthesis and Biological Evaluation of N-Heterocyclic Substituted Fluoro-Benzothiazole Sulphonamido Analogs as a Potential Therapeutic Agents

Author(s) -

Sri Ranga. T,

Neelesh Chaubey

Publication year - 2022

Publication title -

journal of biomedical and pharmaceutical research

Language(s) - English

Resource type - Journals

eISSN - 2589-8752

pISSN - 2279-0594

DOI - 10.32553/jbpr.v11i1.893

Subject(s) - benzothiazole , chemistry , pyrazole , docking (animal) , combinatorial chemistry , molecule , ethanol , in vitro , ethylene , stereochemistry , organic chemistry , biochemistry , catalysis , medicine , nursing

The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline to get 2-amino-6-fluoro-7-chloro (1,3) benzothiazole (I), this was treated with anilino-s-methyl ethylene cyanoacetamide in the presence of ethanol to get desired molecules. The synthesized targeted molecules are characterized, docked and screened for their invitro antidiabetic properties. Keywords: Fluorobenzothiazole, Docking, antidiabetic

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