Open AccessSynthesis and Biological Evaluation of N-Heterocyclic Substituted Fluoro-Benzothiazole Sulphonamido Analogs as a Potential Therapeutic Agents
Author(s) -
Sri Ranga. T,
Neelesh Chaubey
Publication year - 2022
Publication title -
journal of biomedical and pharmaceutical research
Language(s) - English
Resource type - Journals
eISSN - 2589-8752
pISSN - 2279-0594
DOI - 10.32553/jbpr.v11i1.893
Subject(s) - benzothiazole , chemistry , pyrazole , docking (animal) , combinatorial chemistry , molecule , ethanol , in vitro , ethylene , stereochemistry , organic chemistry , biochemistry , catalysis , medicine , nursing
The present investigation is aimed to synthesize fluorobenzothiazole comprising sulphonamido pyrazole analogs starting from fluoro-chloroaniline to get 2-amino-6-fluoro-7-chloro (1,3) benzothiazole (I), this was treated with anilino-s-methyl ethylene cyanoacetamide in the presence of ethanol to get desired molecules. The synthesized targeted molecules are characterized, docked and screened for their invitro antidiabetic properties.
Keywords: Fluorobenzothiazole, Docking, antidiabetic