Open AccessDEVELOPMENT AND EVALUATION OF MEDICATED CHEWING GUM OF RALOXIFENE HYDROCHLORIDE
Author(s) -
Rikin Patel,
Jignesh Darji,
Nikunj Patadiya,
Mitesh Thummar
Publication year - 2021
Publication title -
international journal of pharmaceutical and biological archive
Language(s) - English
Resource type - Journals
ISSN - 2349-2678
DOI - 10.32553/ijpba.v9i3.189
Subject(s) - aspartame , plasticizer , chemistry , polyvinyl alcohol , chromatography , mannitol , buccal administration , solubility , chewing gum , pharmacology , organic chemistry , food science , medicine
In this study we formulate Raloxifene hydrochloride, edicated chewing gum to overcome first pass metabolism of it so bioavability increase of drug. We take polyvinyl acetate as chewing gum base. Aspartame, mannitol and sucrose as sweetener. Glycerin as a plasticizer. Beta-cyclodextrine as solubility enhancer and taste masking agent. First we evaluate the API by its melting point after we derived its calibration curve. After this we select proper ratio of Beta-cyclodextrine and API. After we study drug and excipients compatibility by using FTIR. XRD study perform for API and formulation. After we formulate our formulation and perform post-evaluation study like hardness, weight variation, % drug content and % drug release. From all formulation F5 formulation shows best % drug release and % drug content. After we perform stability study for our formulation and after study no major change show in formulation. And in last we perform buccal permeability study. On basis of all study results we can say that our formulation is successfully formed.
Keywords: Raloxifene hydrochloride, Medicated chewing gum, Buccal permeation, Osteoporosis.