POTENTIAL TREATMENT OPTION FOR COVID 19 RELATED ANOSMIA - CHAMOMILE (MATRRICARIA CHAMOMILLA) EXTRACT NASAL IRRIGATION - A LITERATURE REVIEW.

Corona virus or Covid-19 infection that has rapidly evolved into a global pandemic shortly after its emergence in China in December 2019, demands smart, preventive and treatment recommendations especially related to its early onset symptoms. Anosmia, has now been identified among one of the earliest presenting symptoms in Covid-19 patients. Reports of anosmia in otherwise asymptomatic persons have led to interest in this sign as a potential early indicator of this disease Medical publications about anosmia with COVID-19 are still uncertain of its causative mechanism. The aim of this review is to provide literature review, as well as evidence-based recommendations for the management of patients with COVID-19 related anosmia, using Chamomile (Matrricaria chamomilla) extract nasal irrigation. Extensive database search from PubMed, Cochrane library, and Web of science, gray literature searches from Google Scholar, WHO and Traditional Persian Medicine textbook search such as Makhzan al Adwiyehe was performed. To support the literature, 8 most recent articles published in current year including systematic reviews and meta-analysis as well as clinical trial studies were finally selected to see the effectiveness of Chamomile in treatment of various symptoms of Covid-19. Chamomile (Matrricaria chamomilla) extract based on its pigenin and Luteolin (causing reduction of leukocyte infiltration), a-Bisabolol (which has anti-inflammatory role), Chamazulene (that provides anti-inflammatory and antipyretic role), Guaiazulene (antipyretic), Matricin (Anti-inflammatory role) and other appreciated roles mentioned in this study may serve as a promising treatment for Covid-19 induced anosmia, especially when used as nasal irrigation.  Keywords: Chamomile, Covid-19 related Anosmia, Babouneh, loss of smell.