Open AccessSTUDY OF SERUM LIPID PROFILE IN BETA-THALASSEMIA MAJOR PATIENTS
Author(s) -
Sandeep Kulhari,
Deepak Choudhary
Publication year - 2021
Publication title -
international journal of medical and biomedical studies
Language(s) - English
Resource type - Journals
eISSN - 2589-8698
pISSN - 2589-868X
DOI - 10.32553/ijmbs.v5i8.2126
Subject(s) - hypocholesterolemia , thalassemia , lipid profile , medicine , cholesterol , beta thalassemia , hemolytic anemia , endocrinology , hemolysis , blood lipids , gastroenterology
Background: Beta-thalassemia is the commonest single-gene disorder in the Indian population. Beta thalassemia major is caused by complete absence of beta globin chain production resulting from reduced synthesis of one or more globin chains which can be caused by different globin gene mutation resulting in ineffective hematopoiesis, increased hemolysis and early onset anemia.
Methods: A cross-sectional; case control study was done on 50 diagnosed Cases of beta-thalassemia major in the age group of 1 year to 18 years receiving regular blood transfusions; not suffering from any ailment or any other disease leading to deranged lipid profile were included. In controls; 50 normal healthy children were included.
Results: Lipid analyses of controls and thalassemic children. It is clear from the results that beta thalassemia major patients had significantly lower total cholesterol (TC), high-density lipoprotein cholesterol (HDL) and low-density lipoprsotein cholesterol (LDL) compared with controls (p<0.001).
Conclusion: Lipid profile in Beta thalassmia patients show significantly low levels of total cholesterol, LDLC and HDL-C.
Keywords: Beta Thalassemia Major, Lipid Profile, Hypocholesterolemia.