Open AccessTO STUDY OF LDH LEVEL IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS
Author(s) -
Sudhir Mathur,
Kali Charan Sonkriwal
Publication year - 2020
Publication title -
international journal of medical and biomedical studies
Language(s) - English
Resource type - Journals
eISSN - 2589-8698
pISSN - 2589-868X
DOI - 10.32553/ijmbs.v4i8.1368
Subject(s) - medicine , copd , lactate dehydrogenase , hyperinflation , dynamic hyperinflation , respiratory system , cardiology , gastroenterology , pulmonary disease , pneumonia , respiratory failure , heart failure , lung , lung volumes , enzyme , monetary policy , biochemistry , chemistry , monetary economics , economics
Background: Chronic obstructive pulmonary disease (COPD) is a progressive disease of the lungs characterized by structural changes such as emphysema, airflow limitation, dynamic hyperinflation, air trapping, and peribronchial fibrotic remodeling of the lungs with significant systemic inflammatory components, induced by chronic exposures to smoking and/or occupational or environmental sources.
Methods: It is a case control study of 100 subjects divided into two groups including 50 healthy controls and 50 cases of COPD. Patients with history of respiratory infection, pneumonia, coronary heart disease, heart failure, and neuromuscular disease, renal and hepatic dysfunction were excluded.
Results: The statistically significant increased value of serum lactate dehydrogenase in cases as compared to control group with p value<0.05.
Conclusion-Rise in serum LDH levels, though known to occur in many respiratory conditions, has not been studied in depth. Based on our study results, we have proved that patients with COPD have raised serum LDH levels.
Keywords: COPD, Lactate dehydrogenase, Smoking.