EVALUATION OF LIPID PROFILE IN CASES SUFFERED FROM RHEUMATOID ARTHRITIS

Rheumatoid arthritis is a chronic systemic inflammatory disease of undetermined etiology involving primarily the synovial membranes and articular structures of multiple joints. The disease is often progressive and results in pain, stiffness, and swelling of joints. In late stages, deformity and ankylosis develop. Rheumatoid arthritis can also cause significant extra-articular manifestations most probably related to systemic inflammation. Hence based on above findings the present study was planned for Evaluation of Lipid Profile in Cases Suffered from Rheumatoid Arthritis. The present study was planned in Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India. In the present study 50 patients were evaluated. Out of that 25 cases of the arthritides were enrolled in Group A and remaining 25 control cases were evaluated in the Group B. For the biochemical parameters to be analyzed, blood sample were drawn from the anticubital vein avoiding venostasis. In all subjects a blood sample was collected after an overnight fast plain vials are used for the determination of lipid profile, Total cholesterol and HDL Cholesterol were measured by Henly‟s method. Serum triglyceride was estimated by Rosenberg and Gottfrieds. The data generated from the present study concludes that the lipid profile is altered in Rheumatoid arthritis characterized by low TC and LDL with lower RA factor titres. However, the mean triglycerides, HDL, LDL, VLDL, TC/HDL and mean LDL/HDL did not show a significant difference between subgroups of the patients having different titres of RA factor. Keywords: Lipid profile, Rheumatoid arthritis, Periarticular osteopenia, Hypercholesterolemia, Hypertriglyceridemia, RA factor, etc.