EVALUATION OF CHANGES IN LEVELS OF GLYCATED HEMOGLOBIN, TOTAL PROTEIN AND ALBUMIN IN PATIENTS DIAGNOSED WITH TYPE 2 DIABETES MELLITUS

Insulin resistance in Type 2 diabetes mellitus metabolism of carbohydrates, lipids and proteins gives an estimate of the average blood glucose the previous three months in diabetes. Protein and HbA1c have been shown to be involved complications of diabetes mellitus. Hence based on above findings the present study was planned for Evaluation of Changes in Levels of Glycated Hemoglobin, Total Protein and Albumin in Patients Diagnosed with Type 2 Diabetes Mellitus. The present study was planned in Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India. In the present study 50 cases were evaluated. The 25 cases were enrolled on the Group A as normal cases in Control group. The remaining 25 cases were enrolled in the Group B as Diabetic Patients as study group patients. Glycated Haemoglobin level was determined using immunoturbidimetric method as described by Wolf et al., (1984). Serum albumin level was estimated Bromo Cresol green Method as described by Doumas et al., (1971). Estimation of serum total protein level was done using Biuret Method according to Weichselbaum, (1946). The data generated from the present study concludes that significantly higher mean levels of HbA1c in the diabetic patients compared with the control subjects. However, the mean serum of levels of Albumin and total protein did not differ significantly when compared between the diabetic patients and controls. This finding implies that there was a poor glycemic control in the diabetic subjects studied. Therefore, there is need for better management of diabetic patients through medication and use of diet and exercise. Keywords: Albumin, HbA1c, total proteins, Type 2 Diabetes mellitus, etc.