Open AccessPREVALENCE AND PATTERNS OF THE VARIOUS HEMATOLOGICAL MANIFESTATIONS IN PATIENTS OF MYELONEUROPATHIES
Author(s) -
Nosad Husen
Publication year - 2020
Publication title -
international journal of medical and biomedical studies
Language(s) - English
Resource type - Journals
eISSN - 2589-8698
pISSN - 2589-868X
DOI - 10.32553/ijmbs.v4i1.881
Subject(s) - medicine , macrocytosis , bone marrow , pancytopenia , megaloblastic anemia , bone marrow examination , gastroenterology , myelopathy , anemia , physical examination , neurological examination , peripheral neuropathy , surgery , pathology , spinal cord , diabetes mellitus , psychiatry , endocrinology
Background: Patients of neuroloical syndrome (Myeloneuropathy, Myelopathy and Neuropathy) show various haematoloical manifestations. Complete clinical and early Laboratory evaluation help in early identification of these cases and help in prevention of permanent neurological damage.
Material and methods: 81 Patients of myeloneuropathies attending the outpatient’s department neurology were taken. Detailed hematological, biochemical investigations and bone marrow examination was carried-out in all patients as per the protocol.
Results: 81 cases of neurological syndrome were taken these were classified as myeloneuropathy (32), myelopathy (11) and neuropathy (38). Of these 81 patients, 55 (67.9%) were males and 26 (32%) were females (male: female ratio 2.1:1). Peripheral blood examination, bone marrow examination and biochemical evaluation was done in all. Anemia, present in 48 patients (59.2%), Macrocytosis was defined as MCV ≥100 fl, was present in 38 patients (46.9%). Most common finding on bone marrow examination was reversal of myeloid and erythroid ratio (M:E ratio) and was present in more than three-fourth of patients (76.5%). Megaloblastic changes in erythroid cells were present in 42 patients (51.8%). Biochemical tests revealed increased serum LDH in 56.5% of patients. Out of eighty one patients, twenty eight patients (34.5%) were found to be Vitamin B12 deficient.
Conclusions: This study included 81 patients presenting with various neurological syndromes myelopathy, myeloneuropathy and neuropathy with associated myelocognitive and neuropsychiatric features to study the hematological manifestations such as anemia, other cytopenias, macrocytosis, neutrophil hypersegmentation and megaloblastic changes in the bone marrow.