Open AccessCOMPARATIVE STUDY OF CONCURRENT CHEMORADIOTHERAPY VS RADIOTHERAPY ALONE IN LOCALLY ADVANCED HEAD AND NECK CANCER
Author(s) -
Saroj Dhaka,
Neeti Sharma,
Harish Kumar,
Shankar Lal Jakhar,
Atul Tiwari
Publication year - 2019
Publication title -
international journal of medical and biomedical studies
Language(s) - English
Resource type - Journals
eISSN - 2589-8698
pISSN - 2589-868X
DOI - 10.32553/ijmbs.v3i8.502
Subject(s) - medicine , radiation therapy , head and neck cancer , cisplatin , chemotherapy , chemoradiotherapy , head and neck , toxicity , chemo radiotherapy , paclitaxel , induction chemotherapy , oncology , adverse effect , surgery
The purpose of the study was to assess difference in the treatment response and toxicity profile among two groups of unresectable locally advanced head and neck malignancies receiving concurrent chemo-radiotherapy versus radiotherapy alone after completing neoadjuvant chemotherapy.
50 patients received neoadjuvant chemotherapy (inj. paclitaxel 175 mg/m2 D1 , Cisplatin 80mg/m2 devided in 2 days & inj 5FU 1gm/m2 iv d1&d2).Then randomly allotted into above two groups to receive 66 Gy fractionated RT alone versus RT along with concurrent 3 weekly inj Cisplatin 80mg/m2 devided in two days. Disease response was evaluated by RECIEST criteria.
All patients tolerated treatment well, no major adverse effects were monitored in two groups. There was no significant statistical difference in treatment response, which was found 88% vs 80% in concurrent CTRT vs RT alone .however toxicity profile was higher in concurrent CTRT group. The 6 months PFS were 83.3% and 78.3% in CTRT and RT alone groups respectively ;(x2=0.196, p value>.05)
Keywords: Radiotherapy alone, Induction chemotherapy, Unresectable locally advanced head and neck cancer.