ROLE OF TOPICAL APPLICATION OF NANO SILVER ON ULCER HEALING: A COMPARATIVE STUDY

Background: The disruption of cellular flow of any tissue or its integrity cause wounds which associated with loss of function however, etiology is highly diverse. Among the etiological factors, they can be physical, chemical and surgical and even microbial injuries. Therefore, correction of damaged tissue or wound management plays a significant role in better quality of life to the patient Material & Methods: The present study was prospective comparative interventional study 100 Patients who had ulcers were enrolled from outdoor and from ward by simple random sampling. Clearance from Institutional Ethics Committee was taken before start of study. Written informed consent was taken from each study participant. Results: In the present study, among the povidone iodine group, 49 (98%) patients had slough on day 1st, 04 (8%) patients had slough after 1 week, 40 (80%) patients had slough after 2 weeks, 33 (66%) patients had slough after 3 weeks, 19 (38%) patients had slough after 4 weeks, 08 (16%) patients had slough after 5 weeks and 0 (0%) patients had slough after 6 weeks. In the nano silver group, 49 (98%) patients had slough on day 1st, 41 (82%) patients had slough after 1 week, 24 (48%) patients had slough after 2 weeks, 09 (18%) patients had slough after 3 weeks, 03 (06%) patients had slough after 4 weeks, 0 (0%) patients had slough after 5 weeks. We found statistically significant differences on the presence of slough after 2nd week onwards in both groups (p value < 0.05). Conclusions: We concluded from the present study that the topical application of nano silver gel for ulcer dressing shows faster and better healing in comparison to ulcer healing in povidone iodine group. In nano silver group 100% patients had granulation tissue by the end of 5th weeks and none of patients had slough by the end of 5th weeks. Key words: ulcer, healing, nano silver, povidone iodine.