Open AccessUNUSUAL PRESENTATION OF HAIRY CELL LEUKEMIA: A CASE REPORT
Author(s) -
Vartika Sachdeva,
Mansi Kala,
Sushil Kumar Shukla,
Anuradha Kusum,
Kunal Das
Publication year - 2019
Publication title -
international journal of medical and biomedical studies
Language(s) - English
Resource type - Journals
eISSN - 2589-8698
pISSN - 2589-868X
DOI - 10.32553/ijmbs.v3i6.338
Subject(s) - hairy cell leukemia , immunophenotyping , medicine , pathology , hairy cell , bone marrow , leukemia , spleen , biopsy , aplastic anemia , anemia , immunohistochemistry , dermatology , immunology , flow cytometry
Hairy cell leukemia is a chronic B cell lymphoproliferative disorder,which is uncommon and constitutes around two percent of hematolymphoid malignancies. HCL commonly involves bone marrow and spleen and rarely peripheral blood . Splenomegaly is a prominent feature and is seen in around 70 to 100% of HCL cases as reported in various case reports. Sometimes the absence of splenomegaly rules out the diagnosis of HCL and is misdiagnosed as aplastic anemia. Thus the aim of our study is to understand the importance and keep a high level of suspicion in such cases. As in present case there was no evidence of splenomegaly clinically or radiology, but the morphologic features on biopsy had suggested HCL which was further confirmed on immunophenotyping. The purpose of this case report is to highlight the importance of the fact that HCL can present even without splenomegaly.
Keywords: Hairy cell leukemia, Splenomegaly, Immunohistochemistry