Open AccessROLE OF VITAMIN C IN TYPE 2 DIABETES MELLITUS CASES, A STUDY IN VEDANTA INSTITUTE OF MEDICAL SCIENCES
Author(s) -
Umesh Teltumbadr
Publication year - 2019
Publication title -
international journal of medical and biomedical studies
Language(s) - English
Resource type - Journals
eISSN - 2589-8698
pISSN - 2589-868X
DOI - 10.32553/ijmbs.v3i11.775
Subject(s) - medicine , vitamin c , diabetes mellitus , ascorbic acid , vitamin , physiology , body mass index , type 2 diabetes , multivitamin , endocrinology , food science , chemistry
Diabetes is one of the largest emerging global health problem with 415 million people between the ages of 20 and 70 worldwide estimated as having diabetes in 2015 and Type 2 DM (T2DM) accounts for at least 90% of all cases of diabetes. Vitamin C is naturally present in fruit and vegetables, is often added as a preservative to foods/beverages, and is also used as a dietary supplement. As vitamin C is water-soluble, it has a relatively short half-life in the body due to rapid renal clearance and a regular and adequate intake is required to prevent deficiency. In T2DM patients Vitamin C levels are usually low as blood glucose may compete with vitamin C for uptake into cells due to its structural similarity to the oxidised form, and increased oxidative stress may deplete antioxidant stores. MATERIAL AND METHODS: A total of 206 T2DM patients were included in the study and were divided randomly in to 2 groups of 103 each. Participant’s demographic and physical activity was noted. Anthropometric data including the body mass index (BMI) and waist and hip circumference were collected. Glycated haemoglobin (HbA1c) was determined in EDTA blood by standard methods. Fasting glucose was measured in blood collected in fluoride oxalate tubes. The vitamin C concentration of the processed samples was determined. Drug (Vitamin C and Placebo) was issued to patients for duration of thirty days at a time all patients were maintained on their usual dietary pattern while limiting their consumption of vitamin C-rich foods throughout the study. RESULTS: Mean age in Vitamin C group was 46.87 ± 6.77while in placebo group it was 42.11 ± 6.46. There were 56 male and 44 female in Vitamin C group. In Placebo group male and female were 60 and 40 respectively. No statistical significance was observed in both the group.At 12 weeks fasting blood sugar levels were decreased by -23.74± 2.74 in patients receiving Vitamin C while in placebo group reduction was -5.44± 3.77. Post meal blood sugar was reduced by -21.72± 2.45in vitamin C group while in placebo it was -8.11± 2.45.CONCLUSION:Supplementation of Vitamin C in T2DM patients can significantly reduce the blood glucose levels and HbA1C levels.