Open AccessSensitivity and Spesificity of Interleukin 18 as Biomarker for Acute Kidney Injury
Author(s) -
Febri Jaya Gunawan,
Fredi Heru Irwanto,
Andi Miarta,
Theodorus Theodorus
Publication year - 2018
Publication title -
bioscientia medicina
Language(s) - English
Resource type - Journals
ISSN - 2598-0580
DOI - 10.32539/bsm.v2i4.58
Subject(s) - biomarker , medicine , creatinine , acute kidney injury , urine , gastroenterology , renal function , interleukin 6 , incidence (geometry) , urology , inflammation , biology , biochemistry , physics , optics
Background : Incidence of AKI in intensive care unit patients reach 60-70%, and the mortality rate is about 60%. IL-18 is a pro-inflammatory cytokine which increased in endogenous inflammation process. Studies in human showed that IL-18 concentration increased prior to AKI.
Objective : The aims of this research is to determine the sensitivity and specificity of Interleukin-18 urine examination as an early biomarker for acute kidney injury.
Methods : There’re total of 66 subjects who met the inclusion criteria. All the subject were checked for the IL-18 urine level with Cloud Clone kit and creatinine serum were also checked 48 hours after admission.
Results :The results showed in the cut-off point of 411.25 Pg/mL , urine IL-18 has a sensitivity of 54.3 % and specificity 83.9%, positive predictive value 79.17%, negative predictive value 61.9% and accuracy of 68.18%
Conclusions : Our result suggest that IL-18 urine holds a promise as an early biomarker of AKI and more sensitive and specific as an early biomarker for AKI compared to creatinine serum.
Key words : Acute Kidney Injury, Interleukin-18, sensitivity, spesificity