Open AccessThe Role of Estrogen in the Development of Breast Cancer
Author(s) -
Nikki Aldi Massardi
Publication year - 2021
Publication title -
biomedical journal of indonesia
Language(s) - English
Resource type - Journals
eISSN - 2685-0184
pISSN - 2407-7097
DOI - 10.32539/bji.v7i2.280
Subject(s) - breast cancer , estrogen receptor , estrogen , medicine , endocrine system , carcinogenesis , cancer , human breast , receptor , cancer research , endocrinology , hormone , oncology
Breast cancer is a hormone-dependent disease that relies on the mitogenic effect ofestrogen to increase tumorigenesis and tumor growth. Clinically significant levels ofestrogen-α receptor (ERα) expression are seen in 80% of human breast cancers,whereas progesterone receptor is expressed in 55% of human breast cancers. Thesedata are one of the bases for the development of endocrine therapy. Endocrinetherapy is therapy that targets the pathway and synthesis of estrogen, by blocking itvia receptors, reducing circulating levels of estrogen, or suppressing estrogensynthesis in the tissues of women diagnosed with breast cancer.