Study on modifying the Au surface by thiol compound for biosensor application | Zendy

Khoa Thanh Nhat Phan | Zendy; Nguyen Trung Thanh | Zendy; Tuan Van Phan | Zendy; Binh Van Pham | Zendy; Tung Pham | Zendy; Tuyen Thi Thanh Le | Zendy; Hien D. Tong | Zendy

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Study on modifying the Au surface by thiol compound for biosensor application

Author(s) -

Khoa Thanh Nhat Phan,

Nguyen Trung Thanh,

Tuan Van Phan,

Binh Van Pham,

Tung Pham,

Tuyen Thi Thanh Le,

Hien D. Tong

Publication year - 2016

Publication title -

science and technology development journal

Language(s) - English

Resource type - Journals

ISSN - 1859-0128

DOI - 10.32508/stdj.v19i4.691

Subject(s) - glutaraldehyde , cysteamine , biosensor , horseradish peroxidase , thiol , amine gas treating , chromogenic , chemistry , surface modification , combinatorial chemistry , chemical engineering , materials science , nanotechnology , chromatography , organic chemistry , enzyme , engineering

In cantilever-based biosensor, Au surface plays two essential roles: as a surface to reflect laser beam and as a surface to be modified and thus functionalize the sensor. In this paper, we researched on modifying the Au surface by cysteamine and glutaraldehyde to make it reactive toward amine substances. Cysteamine concentration, cysteamine treatment time and glutaraldehyde treatment time were investigated to find optimal values. The data of chromogenic reaction catalyzed by horseradish peroxidase (HRP) and the data of water contact angle measurement were combined to find the optimal values. The results showed that the modification with 5 mM cysteamine in ethanol for 16 h and glutaraldehyde for 1 h would create the Au surface which can react optimally with amine substances.

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