Friedel-Crafts acetylation of indole, 5-methoxyindole and 5-chloroindole using copper triflate under microwave irradiation | Zendy

Hai Truong Nguyen | Zendy; Phuong Hoang Tran | Zendy

Open Access

Friedel-Crafts acetylation of indole, 5-methoxyindole and 5-chloroindole using copper triflate under microwave irradiation

Author(s) -

Hai Truong Nguyen,

Phuong Hoang Tran

Publication year - 2016

Publication title -

science and technology development journal

Language(s) - English

Resource type - Journals

ISSN - 1859-0128

DOI - 10.32508/stdj.v19i4.621

Subject(s) - friedel–crafts reaction , acetic anhydride , acetylation , catalysis , trifluoromethanesulfonate , indole test , reagent , chemistry , microwave irradiation , organic chemistry , copper , nuclear chemistry , acylation , polymer chemistry , medicinal chemistry , biochemistry , gene

Friedel-Crafts acetylation is an important reaction in organic synthesis processes. Acetylation of indole derivatives with acetic anhydride as acylating reagent using Cu(OTf)2 as a catalyst has been investigated under microwave irradiation. Different from traditional Lewis acidic catalyst, Cu(OTf)2 was found to be an efficient catalyst for Friedel-Crafts acetylation of indoles under mild conditions. Moreover, Cu(OTf)2 was safe-to-handle, recovered and reused several times without significant loss of catalytic activity.

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