Open AccessFriedel-Crafts acetylation of indole, 5-methoxyindole and 5-chloroindole using copper triflate under microwave irradiation
Author(s) -
Hai Truong Nguyen,
Phuong Hoang Tran
Publication year - 2016
Publication title -
khoa học công nghệ
Language(s) - English
Resource type - Journals
ISSN - 1859-0128
DOI - 10.32508/stdj.v19i4.621
Subject(s) - friedel–crafts reaction , acetic anhydride , acetylation , catalysis , trifluoromethanesulfonate , indole test , reagent , chemistry , microwave irradiation , organic chemistry , copper , nuclear chemistry , acylation , polymer chemistry , medicinal chemistry , biochemistry , gene
Friedel-Crafts acetylation is an important reaction in organic synthesis processes. Acetylation of indole derivatives with acetic anhydride as acylating reagent using Cu(OTf)2 as a catalyst has been investigated under microwave irradiation. Different from traditional Lewis acidic catalyst, Cu(OTf)2 was found to be an efficient catalyst for Friedel-Crafts acetylation of indoles under mild conditions. Moreover, Cu(OTf)2 was safe-to-handle, recovered and reused several times without significant loss of catalytic activity.