Open AccessMicrowave-assisted intramolecular FriedelCrafts acylation of some aryl aliphatic acids using Gd(OTf)3/ [BMI]BF4 catalytic system
Author(s) -
Phuong Hoang Tran,
Vy Hieu Huynh,
Hai N. Tran,
Thạch Ngọc Lê
Publication year - 2016
Publication title -
khoa học công nghệ
Language(s) - English
Resource type - Journals
ISSN - 1859-0128
DOI - 10.32508/stdj.v19i2.803
Subject(s) - acylation , intramolecular force , catalysis , friedel–crafts reaction , aryl , chemistry , yield (engineering) , medicinal chemistry , organic chemistry , lewis acids and bases , materials science , alkyl , metallurgy
Intramolecular Friedel–Crafts acylation of aryl acids is a “green” reaction and environmentally benign, generates some valuable intermediated compounds for pharmaceutical uses. In addition, metal triflates under microwave irradiation are efficient catalysts, solving many problems when using traditional Lewis acids. Gd(OTf)3/[BMI]BF4, a good catalyst for the intramolecular Friedel–Crafts acylation under mild condition with high yield, reduced the reaction time and pollution. Furthermore, Gd(OTf)3 in [BMI]BF4 was easily recovered and reused without significant loss of its activity