Open AccessSTUDY ON PREPARATION OF CHITOSAN NANOPARTICLE AS PROTEIN DELIVERY CARRIER FOR DRUG DELIVERY APPLICATION
Author(s) -
Tuyet Thi Anh Duong,
Khuong Vo,
Phuong Hue Phan,
Phong Nguyen
Publication year - 2011
Publication title -
khoa học công nghệ
Language(s) - English
Resource type - Journals
ISSN - 1859-0128
DOI - 10.32508/stdj.v14i4.2048
Subject(s) - chitosan , nanoparticle , drug delivery , chemical engineering , drug carrier , materials science , nuclear chemistry , chemistry , nanotechnology , organic chemistry , engineering
This work investigates the polyanion initiated gelation process in fabricating chitosan (CS)-tripolyphosphate (TPP) nanoparticle intended to be used as protein delivery carrier. Variations in cross-linking agents, CS/TPP weight ratio and solution pH were investigated. The chitosan nanoparticles were characterized by several analytical techniques such as FT-IR, XRD, FE_SEM and TEM. Finally, protein loading efficiency (LE) and protein loading capacity (LC) were investigated.