Open AccessSYNTHESIS OF NOVEL URSOLIC ACID DERIVATIVES
Author(s) -
Phuong T. Tran,
Phung Kim Phi Nguyen,
Quan Pham,
Tong Thanh Danh
Publication year - 2011
Publication title -
khoa học công nghệ
Language(s) - English
Resource type - Journals
ISSN - 1859-0128
DOI - 10.32508/stdj.v14i3.1963
Subject(s) - ursolic acid , chemistry , yield (engineering) , combinatorial chemistry , proton nmr , stereochemistry , chromatography , materials science , metallurgy
Some novel Ursolic Acid (UA) derivatives were designed and synthesized with substitution at positions of C-3-OH and C-28-COOH of UA, the product (1)-(6) has the yeild higher than (7)-(9), in reaction UA with CDI (10) has medium yield. These compounds showed ability ester reaction to product was easily, form these products give pharmacological activity better than UA .Their structures were confirmed using 1H-NMR.