Open AccessMandibular Osteonecrosis Induced by Bisphosphonates in a Carrier of Chronicle Kidney Disease
Author(s) -
Kaohana da Silva,
Greison de Oliveira,
Eleonor Álvaro Garbin-Júnior,
Natasha MagroErnica,
Geraldo Luiz Griza,
Ricardo Augusto Conci,
Fabiana Seguin
Publication year - 2018
Publication title -
international journal of medical and surgical sciences
Language(s) - English
Resource type - Journals
eISSN - 0719-532X
pISSN - 0719-3904
DOI - 10.32457/ijmss.2017.005
Subject(s) - medicine , osteonecrosis of the jaw , bone resorption , kidney disease , multiple myeloma , renal function , bone disease , disease , adverse effect , osteoporosis , urology , bisphosphonate
The bisphosphonates are synthetic substances of inorganic pyrophosphate that have been the basis of treatment of patients with osteolytic diseases, such as multiple myeloma, malignant hypercalcemia, Paget's disease, or patients with bone metastases. Its main pharmacological effect is inhibition of bone resorption caused by osteoclasts, which have a reduced function. Their adverse effects are infrequent but include pyrexia, impaired renal function, hypocalcemia, and more recently, maxillo-mandibular ostenecrose induced bofosfonatos. In this report we describe a clinical case of jaw osteonecrosis induced by bisphosphonates in patient with chronic kidney disease and the treatment protocol performed.