Open AccessNEFROPROTECTOR EFFECT OF CURCUMIN (CURCUMA LONGA) AND VITAMIN E (α-TOCOPHEROL) IN WISTAR STRAIN RATS AFTER CISPLATIN TREATMENT
Author(s) -
Binsar Marshall Maranatha Sirait,
Wahjoe Djatisoesanto,
Soetojo Soetojo
Publication year - 2021
Publication title -
jurnal urologi indonesia (indonesian journal of urology)
Language(s) - English
Resource type - Journals
ISSN - 2355-1402
DOI - 10.32421/juri.v28i1.704
Subject(s) - curcumin , creatinine , vitamin e , curcuma , vitamin , cisplatin , medicine , blood urea nitrogen , renal function , pharmacology , endocrinology , antioxidant , chemotherapy , chemistry , biochemistry , traditional medicine
Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p 0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin.